Histological and Immunochemical Characteristics of Benign Prostatic Hyperplasia in the Sudanese Patients

Ashraf Mohamed Elsayed Ali SAKRAN; Anil Kumar Chhotalal Mithani; Hassan Elsiddig Hassan Faragalla; Abdullah Galil Alkushi; Amal Yousif Ahmed Elhaj MUSTAFA

Volume : VI, Issue : X, October - 2016

Histological and Immunochemical Characteristics of Benign Prostatic Hyperplasia in the Sudanese Patients

Ashraf Mohamed Elsayed Ali Sakran, Anil Kumar Chhotalal Mithani, Hassan Elsiddig Hassan Faragalla, Abdullah Galil Alkushi, Amal Yousif Ahmed Elhaj Mustafa

Abstract :

Background and objective: Benign prostatic hyperplasia (BPH) is one of the most common condition affecting men over 40 years and may be complicated by urine retention. The degree of hyperplasia seems to vary due to race. Little is known about the benign prostatic hyperplasia in Sudanese population. Accordingly, this study investigates benign prostatic hyperplasia complicated by urine retention among Sudanese, using, histological and immunochemical means. Methodology : Hospital based, descriptive study consisted of 60 cases, divided into clinical and cadaveric groups. The clinical group of 50 cases were above the age of 40 years, who presented to Urology Department ,Omdurman Teaching Hospital. They were diagnosed as benign prostatic hyperplasia with urine retention. The cadaveric group of 10 cases, was selected from Omdurman Teaching Hospital, Department of Forensic Medicine – Mortuary. The prostates of the two groups were processed histopathological study. The findings were analyzed by using Statistical Package for Social Sciences (SPSS) to compare the results in the same group and between the two groups. Results: showed, the age was found to be a risk factor for benign prostatic hyperplasia. Histopathologically, this study revealed; the ratio of smooth muscle of hyperplastic prostate stroma was about 40% and stroma / epithelium + glandular lumen ratio was 1/1 in both groups. No difference in the percentage of connective, muscular and glandular tissues between the two groups. Immunochemically, in the clinical group, total PSA level was found to be higher in BPH Sudanese patients (mean= 8.75 ng/ml) than what is reported internationally . Free PSA mean value was 2.54 ng/ml and the ratio F/T PSA mean was 27.27%. Total PSA and free PSA increases with age in BPH. Free PSA increases with total PSA. The ratio F/T PSA increases with the free PSA. Free PSA and the ratio of F/T PSA are more accurate in diagnosis of BPH than the total PSA. Conclusion: This study has proved that, the most reliable diagnosis for Sudanese patients with criteria of soft prostate, total PSA less than 8.75ng/ml, free PSA more than 2.5ng/ml and F/T PSA ratio of more than 25%; is benign prostatic hyperplasia. These findings should be considered by the physicians.