HISTOMORPHOLOGICAL SPECTRUM OF PROSTATIC LESIONS: AN INSTITUTIONAL STUDY IN NORTH MAHARASHTRA

Dr Kunal S Deore; Dr Rajeshree R Gaware; Dr Shubhangi S Rairikar

Volume : IX, Issue : VIII, August - 2019

HISTOMORPHOLOGICAL SPECTRUM OF PROSTATIC LESIONS: AN INSTITUTIONAL STUDY IN NORTH MAHARASHTRA

Dr Kunal S Deore, Dr Rajeshree R Gaware, Dr Shubhangi S Rairikar

Abstract :

Background: Prostatic diseases like inflammation, benign prostatic hyperplasia and tumors are important causes of mortality and morbidity in elderly males. The second most common cancer among males is prostate cancer, next to lung cancer worldwide. Transrectal needle biopsy is a quite commonly done diagnostic procedure. Transurethral resection of prostate (TURP) is most frequently performed urological procedure in surgical treatment and total prostatectomy is less commonly performed to treat men with Prostatism. The purpose of this study is to evaluate histomorphological spectrum of prostate lesions in TURP, transrectal needle biopsy and total prostatectomy specimens. Methods: The present study includes 269 cases of Prostate biopsies which included TURP, transrectal needle biopsy of prostate and total prostatectomy specimens received from January 2017 to June 2019 in the department of pathology, SMBT Institute of medical sciences and research centre, Igatpuri, Nashik. H and E stained sections were examined. The relevant clinical details pertaining to age, clinical complaints and microscopic details were analysed and compared with other similar studies. Results: Of the total 269 Prostate specimen, 214 (79.5%) were of benign hyperplasia, 28 (10.49%) were of prostatic intraepithelial neoplasia (PIN) and 27 (10.01%) cases were malignant. Benign prostatic hyperplasia (BPH) with prostatitis accounted for 68.4% of Prostate specimen. Less frequent findings were granulomatous prostatitis in 0.74%. All the 27 cases of prostate cancer were adenocarcinoma, 20 of which were moderately differentiated, 4 were poorly differentiated and 3 were well differentiated adenocarcinoma. Conclusions: The present study showed that non–neoplastic lesions of prostate are more common than neoplastic ones. The most frequently encountered prostatic lesion was BPH, most commonly found in the age group of 61 –70 years. The malignant lesions were common among the males of more than 60 years. Transrectal needle biopsy of prostate and TURP can be helpful in early identification of premalignant lesions and incidental prostate cancer which can improve the treatment outcome of patients.