Volume : VIII, Issue : I, January - 2018

Histopathological effects of Doxorubicin on heart of Wistar albino rats.

Arish Nazir Shora, Uzma Rasool, Afshan Saleem

Abstract :

 

Introduction: – Ideal anticancer drugs should eradicate cancer cells without harming normal tissues. Unfortunately, no currently available agents meet these criteria, and clinical use of these drugs involves a weighing of their benefits against their toxicity in search for a favourable therapeutic index. Methods: – experimental animals were divided into 4 groups, control, low dose, therapeutic and high dose respectively. After giving respective doses and sacrificing the animals organs were taken and observed grossly and on under light microscopy.  Result: – microscopic changes were observed in all groups except control group. Low dose group showed less change while therapeutic group showed most of the changes which were observed by other authors. High dose group showed marked toxic changes. Conclusion: – The present study showed that the toxicity pattern is almost same in low and therapeutic doses of doxorubicin, and this could be of immense value while treating the carcinoma patients while in high doses it cause severe toxicity on heart.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Arish Nazir Shora, Uzma Rasool, Afshan Saleem, Histopathological effects of Doxorubicin on heart of Wistar albino rats., INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-1 | January-2018

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