Volume : V, Issue : VIII, August - 2015

HOMA–IR AND RATIOS OF TG/HDL AND TC/HDL AS INDICATORS OF INSULIN RESISTANCE IN PATIENT WITH METABOLIC SYNDROME AND TYPE 2 DIABETES MELLITUS

Ayesha Zakira Shaikh, Z. G. Badade, Suma Susan Thomas

Abstract :

Objectives: The aim of the study was to compare the ratios of TG/HDL and TC/HDL with HOMA–IR as indicators of Insulin Resistance in patients with Metabolic Syndrome and Type–2 Diabetes Mellitus. Materials and methods: Total 120 patients were recruited in the study after obtaining informed consent. They were divided in three groups. Group I included healthy individuals as control (n = 40), Group II included patients with metabolic syndrome (MS) (n = 40) and Group III included patients withtype 2 diabetes mellitus (n = 40). Result: There was significant difference between the anthropometric parameters and lipid parameters in control and study groups (p < 0.05). Significant positive correlation was seen between the regression model of HOMA–IR and TC/ HDL(p<0.009) and HOMA–IR and TG/HDL(p<0.01) in Metabolic Syndrome patients.Alsosignificant positive correlation was seen between the regression model of HOMA–IR and TG/HDL and HOMA–IR and TC/HDL (p≤0.001) in patients withtype–2 diabetes mellitus. Conclusion: We propose that the TG/HDL and TC/HDL ratios serve as an easily available and economic marker for the busy clinicians to identifying insulin resistance in metabolic syndrome patients. The combination of these evaluated markers may identify a group of patients with a more marked risk for insulin resistance and cardiovascular disease risk.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Ayesha Zakira Shaikh, Z.G.Badade, Suma Susan Thomas Homa-Ir and Ratios of Tg/Hdl and Tc/Hdl as Indicators of Insulin Resistance in Patient with Metabolic Syndrome and Type 2 Diabetes Mellitus Indian Journal of Applied Research, Vol.5, Issue : 8 August 2015

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