Honokiol loaded PLGA nanoparticles with modified surface by chitosan

Quyet Nguyen Ngoc; Huan Le Quang; Nhung Hoang Thi My; Duong Le Thi Thuy

Volume : V, Issue : II, February - 2015

Honokiol loaded PLGA nanoparticles with modified surface by chitosan

Quyet Nguyen Ngoc, Huan Le Quang, Nhung Hoang Thi My, Duong Le Thi Thuy

Abstract :

Polymer nanoparticles have become a powerful tool to deliver and to improve effective of anticancer drugs. Recent widespread studies have used poly lactic–co–glycolic acid (PLGA) as useful material to entrap water–insoluble anticancer drugs. However, using PLGA remains some disadvantages such as its low zeta potential, poor mucoadhesivity and permeability which lead to unstable nanoparticle system, low efficiency of drug absorption through gastrointestinal (GI) tract. In this study, PLGA nanoparticles loading honokiol, an insoluble anticancer drug, were improved its quality by modified surface with chitosan (CS), and CS is a mucoadhesive compound contains positive charge, to form PLGA–CS nanoparticles (PLGA–CS NPs). These nanoparticles were prepared by emulsion solvent diffusion method followed by optimized process. Size distribution, zeta potential, morphology and encapsulation efficiency (EE) are measured to evaluate quality of PLGA–CS NPs. Optimized nanoparticles reached zeta potential of +43 mV as well as 253 nm in average of size. PLGA–CS NPs were sphere indicated by SEM images with high homogeneity and polydispersity index (PdI) was 0.070. EE was about 65%. These stable characteristics proclaimed that PLGA–CS nanoparticles were promising insoluble–drug delivery system to conduct further experiments in vivo.