IDENTIFICATION OF LEAD MOLECULE FOR 1TNF RECEPTOR TO TREAT TUBERCULOSIS AND TYPE 2 DIABETES MELLITUS

Chaithra; D.R.; Tanusree Bhattacharya; Kusum Paul

Volume : V, Issue : V, May - 2015

IDENTIFICATION OF LEAD MOLECULE FOR 1TNF RECEPTOR TO TREAT TUBERCULOSIS AND TYPE 2 DIABETES MELLITUS

Chaithra, D. R. , Tanusree Bhattacharya, Kusum Paul

Abstract :

Tuberculosis (TB) is one of the life threatening diseases around the world infected by Mycobacterium tuberculosis. Mycobacteria are resistant to most commonly used antibiotics and drugs. The increasing emergence of drug resistant tuberculosis strains and is one of the common causes of poor response to anti–tubercular treatment these necessitates the development of novel drugs. Diabetes in tuberculosis increases drug resistance strains hence, lead to treatment failure and increases death rates. Previous studies explain that, TNF– alpha gene involved in both tuberculosis and diabetes mellitus type 2. The best ligand for the TNF–alpha was identified, that can act as a drug molecule to cure both the disease at a time