Volume : IV, Issue : II, February - 2014

Imidacloprid Induced Histopathological Alterations in the Kidneys of Male Swiss Albino Mice

Naga Prasanna Meda, V. Viveka Vardhani

Abstract :

Six groups of male Swiss albino mice (A, 0.4 mg/kg bw; B, 0.8 mg/kg bw; C, 1.6 mg/kg bw; D, 3.2 mg/kg bw; E, 4.0 mg/kg bw and F, 8.0 mg/kg bw) (6 in each group) were orally administered with different doses to understand the nephrotoxicity of imidacloprid insecticide. Another group (G) of 6 mice served as controls. Two mice from each of test group were necropsied on day 4, 16 & 30 after treatment; two mice from the control group were also necropsied on the same designated days. Kidney tissues were fixed, sectioned and stained for histopathology. Kidney tissue of test mice in all the groups showed haemorrhages, glomerular atrophy and tubular degeneration and necrosis on day 4, 16 and 30 of experiments. The toxicity of imidacloprid is found to be severe on day 30 of treatment in mice of all the test groups.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Naga Prasanna Meda, V. Viveka Vardhani Imidacloprid Induced Histopathological Alterations in the Kidneys of Male Swiss Albino Mice Indian Journal of Applied Research, Vol.IV, Issue. II

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