Volume : VII, Issue : III, March - 2017

Immune Reconstitution Inflammatory Syndrome in HIV positive patients on Anti–Retroviral therapy

Dr Sivaprakash Varadan, Dr K Madhavan, Dr V. Priyadharshini

Abstract :

 Antiretroviral therapy has led to a significant decline in AIDS – associated morbidity and mortality (1). These benefits are in part a result of partial recovery of the immune system, manifested by increase in CD4 T–lymphocytes counts and decrease in plasma HIV–1 viral loads (2). In some patients, clinical deterioration occurs despite increased CD4 T–lymphocytes and decreased plasma HIV–1 viral loads (3).  This clinical deterioration is due to inflammatory response of the immune system to both subclinical pathogens and residual antigens. Immune Reconstitution Inflammatory Syndrome (IRIS) is defined as a paradoxical deterioration in clinical status after initiating anti –retroviral therapy attributable to the recovery of the immune response to latent or subclinical infection or non–infectious processes. As we have very few Indian studies about IRIS, a study is planned to find the clinical spectrum of IRIS in HIV positive patients visiting a tertiary care center in Chennai    

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr sivaprakash varadan, DR k madhavan, Dr v. priyadharshini, Immune Reconstitution Inflammatory Syndrome in HIV positive patients on Anti–Retroviral therapy, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾3 | March‾2017

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