Immunohistochemical Expression of Stem Cell Marker CD24 In Benign and Malignant Breast Lesions Of Iraqi Women

Prof.Dr.Salem R. Al–aubaidy; Dr. Hassanien G. Hussein; Dr.Ameer D. Hameedi

Volume : V, Issue : III, March - 2015

Immunohistochemical Expression of Stem Cell Marker CD24 In Benign and Malignant Breast Lesions Of Iraqi Women

Prof. Dr. Salem R. Al Aubaidy, Dr. Hassanien G. Hussein, Dr. Ameer D. Hameedi

Abstract :

CD24 is a small cell surface protein molecule anchored by glycosyl–phosphotidyl–inositol in a wide variety of cancer cell.CD24 is involved in cell adhesion and metastasis. We aimed to evaluate CD24 expression in Fioadenoma east lesion and Invasive east ductal carcinoma and to investigate the relationship between CD24 expression and clinicopathological parameters. The study included 72 Invasive ductal carcinoma (IDC) and 34 Fioadenoma east lesion (FA). All cases were reevaluated histopathologically and immunohistochemically was performed with monoclonal CD24 antibody. The results demonstrated that CD24 expression was significantly higher in IDC than FA east lesion. CD24 staining was detected predominantly in IDC and was significantly increased in high grade IDC. In conclusion, our results suggest that higher CD24 expression may be associated with malignant transformation and progression in east cancer biology.