Immunohistochemistry for detection of ER (Estrogen Receptor), PR (Progesterone Receptor) and HER�2/neu (Human Epidermal Growth Factor Receptor) receptor status and correlation with histopathological grading in breast carcinoma: A study at a tert

Dr Geeta Pachori; Dr Ganpat Raj Puri; Dr Saroj Pachori; Dr Tushar Bayla

Volume : VI, Issue : IX, September - 2016

Immunohistochemistry for detection of ER (Estrogen Receptor), PR (Progesterone Receptor) and HER�2/neu (Human Epidermal Growth Factor Receptor) receptor status and correlation with histopathological grading in breast carcinoma: A study at a tert

Dr Geeta Pachori, Dr Ganpat Raj Puri, Dr Saroj Pachori, Dr Tushar Bayla

Abstract :

In India, Breast Cancer is the leading cause of Cancer. Present study was aimed to study pattern of expression of ER, PR and Her–2/neu in invasive east carcinoma and to correlate their expression with various clinicopathological aspects. The study was conducted from June 2014 to July 2015. Routine H&E staining for histopathological diagnosis and IHC analysis for ER, PR and Her–2/neu was done.Out of 56 cases studied, invasive duct carcinoma was observed in 71.43% cases. The age of patients ranged from 21 to 80 years of age. Majority of tumors were grade II (55.36%) followed by grade I (23.21%). ER, PR and Her–2/neu expression was seen in 75.0%, 60.71% and 39.28% respectively. We concluded that ER, PR and HER–2/neu status correlates well with histopathological grading and other clinico–pathological parameters. Higher number of grade II tumor showed ER, PR positivity as compared to grade III tumors