Impact of high level of Aluminum on Parathyroid hormone in Bauxite dust exposed mine workers

Aruna A. Jawade; Ruchika K. Jain; Shubhangi K. Pingle; Rajani G. Tumane; Lucky R. Thakkar; B. B. Mandal; Pravin N. Soni

Volume : IV, Issue : XII, December - 2014

Impact of high level of Aluminum on Parathyroid hormone in Bauxite dust exposed mine workers

Aruna A. Jawade, Ruchika K. Jain, Shubhangi K. Pingle, Rajani G. Tumane, Lucky R. Thakkar, B. B. Mandal, Pravin N. Soni

Abstract :

Bauxite ore is a major source of aluminium mineral. Dust particles of bauxite ore may be deposited in parathyroid gland and ultimately interrupt the secretion of parathyroid hormone (PTH) and calcium metabolism. In the present exploratory and stratified randomized study, 273 subjects were selected from three different bauxite producing mines. Whole blood and serum samples were used for measurement of Aluminium, PTH and calcium level respectively. The result shows that there is a negative correlation between levels of Al, Ca and PTH. It was also observed that PTH level is significantly decreased (p <0.0001) in experimental group as compared to both the groups. It was also observed that PTH level decreases as the duration of exposure increases. Our preliminary findings suggest that PTH may be used as a potential biomarker for early detection of bauxite dust toxicity among exposed workers. Evaluation of PTH with panel of biomarkers may be helpful for further research on the bauxite toxicity among bauxite dust exposed workers.