Volume : IV, Issue : VI, June - 2014

Impact of Nickel Chloride on Wistar Rat Epididymis: A Biochemical Study

Dr Neena Nair

Abstract :

Nickel, a ubiquitous environmental contaminant, poses a risk to human health. The present study evaluates the effect of nickel chloride as nickel on epididymides of Wistar rats. The rats were provided NiCl2 below LD 50 (250,500 and 1000 ppm) ad libtum for 2– and 4–weeks. Animals were sacrificed after 2– and 4–weeks under light ether anaesthesia. Organ viz. caput and cauda epididymides were excised, trimmed off of extraneous tissues, stored at –70 ? C until the assays were performed. A dose dependent increase (P < 0.05) in lipid peroxidation (MDA) and hydroperoxides concentration as well as catalase activity in caput and cauda epididymides was observed. However, total superoxide dismutase, Cu–Zn superoxide dismutase and Mn– superoxide dismutase activities decreased. Further, the total zinc decreased while total copper concentration increased in the epididymides at all doses. The results indicate that epididymides after NiCl2 intake are vulnerable to oxidative stress which could cause dysfunction and may impair fertility

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr Neena Nair Impact of Nickel Chloride on Wistar Rat Epididymis: A Biochemical Study Indian Journal of Applied Research, Vol.IV, Issue.VI June 2014

Number of Downloads : 662

References :