Volume : VIII, Issue : IV, April - 2018

Impact of poor glycemic control on Serum lipid profile in Type II diabetes mellitus - a comparative study on subjects with Type II diabetes mellitus based on HbA1c levels at Wayanad region

Dr. Balaji. K. , Dr. Rvenugopal, Kj Aparnna, Dr. Desai Pb

Abstract :

Diabetes represents a spectrum of metabolic disorders, which has become a major health challenge worldwide. Diabetes is pandemic in both developed and developing countries. One of the most common problems in diabetic subjects is atherosclerotic cardiovascular disease which is induced by lipid abnormalities. Total 100 subjects were included in the study. Subjects were divided into two groups Group A and Group B. Group A consists of 50 non diabetic subjects with HbA1C<6.5%. Group B consists of 50 diabetic subject with HbA1C>6.5%. The samples were collected and processed as per standard protocol and analysedin BIO–RAD D–10 TM Hemoglobin A1c Program auto analyzer and COBAS INTEGRA 400 PLUS auto analyzer.The group B subjects with HbA1c value >6.5% exhibited a significant increase in FBS, TC, LDL–C, TG, HDL–C, TC/HDL–C ratio compared to group A subjects. The HbA1c showed significant positive relationship with TC (r=0.193), TG (r=0.13), HDL–C (r=0.014), LDL–C (r=0.073).Female diabetic subjects showed higher mean values for FBG, PPBS, TC, TG, and LDL–C than male diabetic subjects.The present study suggested that the glycemic control of the patient has got a strong impact on the serum lipid profile levels and atherosclerosis, CVD and CHD include heart attack and stroke. Subjects should be educated about regular monitoring of profiles and if found to be abnormal, should control blood glucose and cholesterol very effectively. In out diabetic study clearly added value of HbA1C can be monitoring long term glycemic control and as a potential indicator for dyslipidemia in group B subjects. 

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr.Balaji.K., Dr.RVenugopal, KJ Aparnna, Dr.Desai PB, Impact of poor glycemic control on Serum lipid profile in Type II diabetes mellitus‾a comparative study on subjects with Type II diabetes mellitus based on HbA1c levels at Wayanad region, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-4 | April-2018

Number of Downloads : 299

References :