IMPACT OF SERUM URIC ACID LEVELS ON CARDIOVASCULAR OUTCOMES IN THE MYOCARDIAL INFARCTION

Dr. M. PAVAN KUMAR; Dr .N.GURURAJ

Volume : VI, Issue : VI, June - 2016

IMPACT OF SERUM URIC ACID LEVELS ON CARDIOVASCULAR OUTCOMES IN THE MYOCARDIAL INFARCTION

Dr. M. Pavan Kumar, Dr . N. Gururaj

Abstract :

 BACKGROUND: Most sudden deaths in acute myocardial infarction occur within one hour due to ventricular fiillation and also due to left ventricular failure when there is an extensive injury1.Rest of the deaths following myocardial infarction happen within first one week and death cannot be predicted and occurs suddenly. Hence many trials have been conducted to identify markers that would be helpful to predict the risk of such adverse cardiac events. AIM: The aim of this study is ascertain uric acid as a predictor for mortality and morbidity and risk of developing adverse cardiac events like sudden cardiac death and congestive heart failure following acute myocardial infarction. OBJECTIVE: 1.To validate the prognostic significance between quantitative serum uric acid level on admission and high Killip’s class status in acute myocardial infarction. 2. Quantification of incidence of cardiac failure and mortality in relation to serum uric acid levels STUDY DESIGN: prospective observational study MATERIAL AND METHODS: This study included 100 patients of acute myocardial infarction of which patient who had a normal uric acid level were taken as a control group and the rest who had elevated uric acid level were taken up as a study group. Statistical methods: Student t test (two tailed, independent) has been used to find the significance of study parameters on continuous scale between two groups. Chi–square/ Fisher Exact test has been used to find the significance of study parameters on categorical scale between two or more groups. P–value< 0.05 is considered as significant. RESULTS: The mean serum uric acid in males was 6.23 mg/dl and in females was 5.98 mg/dl. In study group 40% are in Killip I&II and 60% in Killip class III&IV in comparison to control group 75% are in Killip I&II and 25% in Killip class III&IV. Incidence of heart failure in total population was 41% in which males were 80%, females were 20 %. In study group 64% developed heart failure in comparison to 73% in control group. Incidence of mortality in patients with study group was 26% and in patients with control group was 6 %. CONCLUSION: Elevated Uric Acid (UA) levels is a good marker of oxidative stress and useful to assess the prognostic events in acute myocardial infarction.