Impact of Sodium Fluoride on Histopathology of  Testes In Albino Mice and Its Recovery with Vitamin – C

Kavitha. N; Praveena. M; Sandeep.V; Jayantha Rao. K

Volume : III, Issue : XII, December - 2013

Impact of Sodium Fluoride on Histopathology of Testes In Albino Mice and Its Recovery with Vitamin – C

Kavitha. N, Praveena. M, Sandeep. V, Jayantha Rao. K

Abstract :

Increasing in–fertility has become a serious issue. Sodium fluoride is wide spread natural pollutant and large number of the world population is exposed to high doses of fluoride. So it is of special concern to investigate the role of the vitamin– C on effect of sodium fluoride on male reproduction. Male albino mice were treated with 5 ppm of sodium fluoride for 7 and 30 days. After stipulated period testes was isolated and histological work was done. Many changes were observed in the testes of the treated mice like severe degenerative changes in seminiferous tubules, reduced spermatozoa, and necrotic changes in spermatids .The administration of ascorbic acid to NaF–treated mice revealed marked recovery from fluoride toxicity. Histological changes of testes show that fluoride toxicity is reversible and transient with ameliorative effects of ascorbic acid.