Improved Overall and Event free survival with adapted Berlin-Frankfurt-Munster (BFM)risk stratified treatment in Pediatric Acute Lymphoblastic leukemia-Single centre Experience from South India

Dr. Rema Ganapathy; Dr. Neeraj Sidharthan; Dr. Manoj Unni; Dr. K. Pavithran; Dr. Arun Philip; Sumi Soman

Volume : IX, Issue : XII, December - 2019

Improved Overall and Event free survival with adapted Berlin-Frankfurt-Munster (BFM)risk stratified treatment in Pediatric Acute Lymphoblastic leukemia-Single centre Experience from South India

Dr. Rema Ganapathy, Dr. Neeraj Sidharthan, Dr. Manoj Unni, Dr. K. Pavithran, Dr. Arun Philip, Sumi Soman

Abstract :

Background: Paediatric acute lymphoblastic leukemia (ALL) has a reported five year overall survival reaching over 90% in high income countries(HICs).Overall survival in India ranged from 45–81%(commonly > 60%) and Event free survival ranged from 41–70%(commonly > 50%) Aim: To analyse the outcome with a uniform protocol adapted from Berlin–Frankfurt–Münster (BFM) protocol used in all Pediatric ALL patients. Method: After institutional research board approval , records of consecutive children with newly diagnosed with B cell and T cell Acute lymphoblastic leukemia/lymphoma (ALL) between 1 and 14 years of age at the time of diagnosis and underwent treatment in the institution from 1/1/10 to 31/12/18 were reviewed .Patient treatment was stratified according to BFM relapse risk criteria to standard risk(SR), Intermediate risk(IR) and high Risk(HR). Results: One hundred and twenty eight children consecutively treated for acute lymphoblastic leukemia/ lymphoma with ages ranging from 1–14 years were analysed. The estimated 5year overall survival and Event free survival by Kaplan meier method were 82.3+/– 3.4% and 79.8+/– 3.6%. Conclusions: Adherence to globally accepted treatment regimens along with best supportive care can ing out results similar to HICs.