In Vitro Screening Research on Detection of Sensibilization to Amoxicillin in Pregnant Women

Andriy Zimenkovsky; Oksana Nepyyvoda; Oksana Gorodnycha; Olexandr Cherpak; Tetiana Ryvak

Volume : V, Issue : VII, July - 2015

In Vitro Screening Research on Detection of Sensibilization to Amoxicillin in Pregnant Women

Andriy Zimenkovsky, Oksana Nepyyvoda, Oksana Gorodnycha, Olexandr Cherpak, Tetiana Ryvak

Abstract :

Aim: To conduct an in vitro screening of pregnant women to detect sensibilization and develop ways of preventing pharmaceutically induced allergy in newborns affected by mother’s sensibility to drugs.Materials and methods: The research’ components included blood samples of pregnant women at different stages of gestational age (n=72).The antibodies’ identification method was conducted through ELISA.Results: show that in 61 (84.7%) patient IgE levels belong to <0> EAST–class, in other words these pregnant women are not sensible to amoxicillin. In addition, 12.5 % of pregnant women are found to have low level to amoxicillin–related IgE and 2.8% of patients have been found to have a higher level. According to the concluded research, 15.3% [95% confidence interval, 7.8–25.7] of pregnant women have shown a higher level of sensitivity to amoxicillin, contrary to the fact that they had never experienced allergic reactions prior. Considering this fact, the possibility of the child receiving a portion of the allergysensible medicine is not excluded. Therefore, the child may be subjected to weakened immune system and allergy based illnesses. Conclusion:We consider development of electronic medication passport – a new perspective way of prognostication, prevention and decrease of allergic reaction risks appeå in pregnant women as well as in their babies. In our opinion the research results received prove the necessity of usage of electronic document suggested by us while developing anch programs on quality improve for rendering medical aid to the pregnant and the newborn in Ukraine.