Volume : III, Issue : VII, July - 2013

In vitro study of the anticoagulant activity of some plant extracts

Narjis Hadi Mansoor Al Saadi

Abstract :

Cardiovascular diseases involving, deep vein thrombosis, strokes, heart attacks, and hypertension are the main causes of morbidity and mortality in world countries. Some plant extracts have the anticoagulant activity for treatment these problems. Our study involved 26 healthy normal individual with no any diseases like diabetes, hypertension, atherosclerosis and cardiovascular disease, their age ranged (19–25) year. Prothrombin time (PT) was tested for each of them then the anticoagulant effect of plant extracts include aqueous red onion extract, garlic oil and grape oil were examined on the blood samples of normal individuals by measuring prothrombin time (PT). For determination the prothrombin time, the plasma sample of each individual was divided into four groups. Group 1 was tested first to determine the normal prothrombin time (positive control group), other three group including three volumes of plant extracts (25, 50 and 75 μL) were added separately to the plasma samples. The results showed that aqueous red onion extract (Allium cepa) have anticoagulant properties through prevention of coagulation process and clot formation. The results showed that there were highly significant differences (p< 0.0001) when added aqueous extract of red onion at volume (25, 50, and 75 µl) into plasma of individual compå with positive control also there was highly significant differences (p< 0.0001) between the groups. Similarly garlic oil showed anticoagulant activity and there were highly significant differences (p< 0.0001) at volume (25, 50, and 75 µl) compå with positive control and there were highly significant differences (p< 0.0001) between the groups whereas grape oil extract did not show any effective anticoagulant (p > 0.05). The results of this study also showed that the sex has a significant effect (p>0.01) between male and female at volume 50 µl and (p< 0.001) at volume 75 µl when added red onion extract, also garlic oil appeared significant differences (p < 0.05) between male and female at volume 25 µl whereas grape oil didn’t show any significant differences (p > 0.05) between sex.  

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Narjis Hadi Mansoor Al-Saadi In vitro study of the anticoagulant activity of some plant extracts Indian Journal of Applied Research, Vol.III, Issue.VII July 2013

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