In Vivo Ameliorative Effect of Amla Extract on  Fluoride Induced Oxidative Stress on Thyroid Gland  in Rats

Dhara D. Vyas; Rajendra N. Bhatt; Mandava V Rao

Volume : III, Issue : XII, December - 2013

In Vivo Ameliorative Effect of Amla Extract on Fluoride Induced Oxidative Stress on Thyroid Gland in Rats

Dhara D. Vyas, Rajendra N. Bhatt, Mandava V Rao

Abstract :

The present study was an attempt to investigate beneficial role of Amla fruit extract on fluoride (F–) induced thyrotoxicity in the rats. The adult male rats were administered 5 (L.D) and 10 (H.D) mg/kg b.w of fluoride orally for 60 days with and without aqueous extract of Amla at a dosage of 20 mg/kg b.w. Amla effectively countered toxic effect of Sodium fluoride (NaF). Compared to NaF alone, combine treatment prevented the NaF induced reduction in body and organ weights as well as decreased antioxidative indices and energy metabolites and mitigation in these thyroid effects was observed in the Amla+NaF fed groups. Thus, excessive F– administration induced thyroid dysfunction in rats; which is mitigated by Amla extract supplementation due to its anti–stress effect.