Volume : VIII, Issue : II, February - 2018

IN-VIVO ANALGESIC ACTIVITY OF NOVEL DERIVATIVES OF 2, 5 DISUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES.

Somashekhar M, R B Kotnal

Abstract :

 

Oxadiazole types of five membered heterocyclic compounds contain oxygen and two nitrogen atoms at position 1, 3 and 4 positions respectively. These derivatives are synthesized by both conventional as well as microwave assisted. As with the azoles, this is also an electronegative ring system with weak basic characteristics due to the inductive effects of the extra hetero atoms. Oxadiazoles are susceptible to nucleophilic attack as because it readily undergoes ring cleavage with aqueous acid or base hence both carbon positions are substituted. 1,3,4– oxadiazoles also display a wide spectrum of activities such as antibacterial, antimalarial, anti– inflammatory, antifungal and anticonvulsant, antihistaminic, anticancerous, and antihypertensive activities. Hence, some new 1,3,4 – oxadiazoles are synthesized and biologically evaluated as analgesic activity according to reaction sequence outlined in scheme. From these 1,3,4–oxadiazoles act as starting material for the synthesis of various derivatives of 1,3,4–oxadiazoles. With the aim of obtaining the new oad spectrum various 1, 3, 4–oxadiazole derivatives, which will devoid of side effects associated with current therapy.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Somashekhar M, R B Kotnal, IN-VIVO ANALGESIC ACTIVITY OF NOVEL DERIVATIVES OF 2, 5 DISUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES., INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-2 | February-2018

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