INCIDENCE OF INTRAUTERINE GROWTH RETARDATION IN PREGNANCIES WITH AND WITHOUT SICKLE CELL DISORDER : A SINGLE CENTRE STUDY

Vishal Kumar Jain; Satyabhuvan Singh Netam; Zeeshan Ateeb Dani; Sanjay Kumar

Volume : VIII, Issue : VI, June - 2018

INCIDENCE OF INTRAUTERINE GROWTH RETARDATION IN PREGNANCIES WITH AND WITHOUT SICKLE CELL DISORDER : A SINGLE CENTRE STUDY

Vishal Kumar Jain, Satyabhuvan Singh Netam, Zeeshan Ateeb Dani, Sanjay Kumar

Abstract :

Objective – This study was to evaluate the difference in incidence of intrauterine growth retardation in pregnancies with and without sickle cell disorder.

Material and methods – This study consisted 44 sickle cell disease (SCD), 95 sickle cell trait (SCT) and 241 normal pregnancy group totalling 380 pregnancies. Study population were matched for age, gravidity and mean blood pressure. Foetal biometric evaluation was done in 2^nd or 3^rd trimester as and when presented. Estimated fetal weight <10^th percentile are considered growth retarded (IUGR).

Result – In 2^nd trimester 23.8% of foetuses of SCD group, 6.7% of foetuses in SCT group and 6.1% of control pregnancy group foetuses were growth retarded. In 3^rd trimester 33.3% of foetuses of SCD pregnancy group, 17.8% of foetuses in SCT group and 10.5% of foetuses in normal pregnancy group were growth retarded. Significant difference in growth retardation was found between study groups as evaluated during 2^nd(p=0 .024) and 3^rd trimester (p=0.022).

Conclusion–SCD and SCT pregnancies are associated with increased risk of IUGR which is more prevalent in SCD pregnancies. Early diagnosis of IUGR is possible by ultrasonography in 2^nd trimester. With timely management we can improve the fetal growth and its outcome.