INCIDENCE OF POLYMORPHISM OF GSTT1 GENE IN BENIGN PROSTATIC HYPERPLASIA IN BASRA PROVINCE

ASAAD MOHAMMED KADHIM; Jihad Abdulameer Ahmed

Volume : V, Issue : XII, December - 2015

INCIDENCE OF POLYMORPHISM OF GSTT1 GENE IN BENIGN PROSTATIC HYPERPLASIA IN BASRA PROVINCE

Asaad Mohammed Kadhim, Jihad Abdulameer Ahmed

Abstract :

Prostate tumor has become a major public health problem concern worldwide for its high morbidity and mortality levels, therefore It is the second leading cause of cancer related to death in the world, on the other hand the prostate tumor is a multiphase process that depend on various risk factors included genetic factors which play an important role in it initiation and progression, so that the GSTT1 gene polymorphisms might be involved in inactivation of procarcinogens that contribute to the genesis and2 progression of cancers. The methodology consist of DNA extraction from 40 patient of benign prostatic hyperplasia and 40 healthy served as controls, then done the amplification of GSTT1 gene to study the polymorphism of it. The results showed that 77.5% of patients of benign prostatic hyperplasia have polymorphism with GSTT1 null genotype when compared with controls. We concluded that the polymorphism of GSTT1 gene may considered as risk factor to initiate prostate tumor.