Volume : III, Issue : XII, December - 2013

Induction of Oxidative Stress by Subchronic Oral Exposure of Sodium Arsenite in Female Rats

Madhuri Mehta, S S Hundal

Abstract :

Arsenic has been recognized as one of the most toxic environmental pollutant. In this study, twenty four adult female rats were divided in to four groups of 6 animals each. Group I animals received distilled water; Group II–IV received sodium arsenite as source of arsenic at the dose of 10, 30 and 50 ppb (μg/L), respectively dissolved in distilled water for 30 days. On completion of the experiment, blood was collected and processed for estimation of superoxide dismutase, catalase, glutathione–S–tranferase, blood glutathione and lipid peroxidation. The levels of plasma transferases, phosphatases, lactate dehydrogenase, proteins, urea and creatinine were also studied. Sub chronic exposure of sodium arsenite significantly decreased the activities of antioxidant enzymes along with an increase in LPO, urea, creatinine, plasma transferases, phosphatases and LDH in treated rats. On the basis of the results, we can conclude that arsenic even at low dose altered the biochemical parameters and induces oxidative stress.  

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Madhuri Mehta, S S Hundal Induction of Oxidative Stress by Subchronic Oral Exposure of Sodium Arsenite in Female Rats Indian Journal of Applied Research, Vol.III, Issue.XII Dec 2013

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