Inflammatory markers high sensitivity C - reactive protein and sialic acid in Hypertension

NAKKEERAN.M; INMOZHI SIVAKAMASUNDARI.R; PERIASAMY.S

Volume : VII, Issue : XI, November - 2017

Inflammatory markers high sensitivity C - reactive protein and sialic acid in Hypertension

Nakkeeran. M, Inmozhi Sivakamasundari. R, Periasamy. S

Abstract :

Acute–phase reactants protein whose concentrations in blood increase/decrease by 25% during inflammation. The synthesis and degradation of sialic acid are distributed in different compartments of the cell and inflammation plays a major role in measurement of inflammatory markers such as high–sensitivity C–reactive protein (hsCRP) may provide a method for detecting individuals at high risk of plaque rupture. CRP has emerged as one of the most important inflammatory marker. Objective: The study was to findout the levels of hsCRP and sialic acid in hypertensive subjectss. Methods: The study included 120 volunteers, who were divided into 40 controls, and 80 hypertensive subjects, between the age group of 30–55 years. hs–CRP, total sialic acid, fasting blood sugar, body mass index and lipid profile were estimated in both groups. Past history of CHD, secondary hypertension and metabolic disorders were excluded. Results: Sialic acid and hs– CRP levels were significantly elevated in the hypertensive group than control group. There was significant correlation between hs–CRP and total sialic acid with systolic and diastolic blood pressure. Conclusion: Our result concluded that higher hsCRP levels are significantly correlated with hypertension subjects; there is an association between serum sialic acid and hs–CRP levels. hs–CRP and total sialic acid were positively correlated with dyslipidemia thus contributing to cardiovascular risk.