INFLUENCE OF IRON DEFICIENCY ANAEMIA ON HAEMOGLOBIN A1C LEVELS IN DIABETIC INDIVIDUALS WITH CONTROLLED PLASMA GLUCOSE LEVELS

DR. DIPANJAN RAKSHIT; PROF. (DR.) IPSITA MAJUMDAR; DR. DEBARSHI JANA

Volume : IX, Issue : II, February - 2019

INFLUENCE OF IRON DEFICIENCY ANAEMIA ON HAEMOGLOBIN A1C LEVELS IN DIABETIC INDIVIDUALS WITH CONTROLLED PLASMA GLUCOSE LEVELS

Dr. Dipanjan Rakshit, Prof. Dr. Ipsita Majumdar, Dr. Debarshi Jana

Abstract :

This case control study was done in the Department of Biochemistry, K.P.C. Medical College, Jadavpur, Kolkata. A total of 140 patients of more than 18 years were studied. All participants were controlled diabetic patients. 140 patients were divided into Case & Control group depending on presence of Iron Deficiency Anaemia. Each group consists of 70 patients. A comprehensive history of Anaemia, Blood loss, duration of diabetes, familial disorders were taken from the selected patients. This study showed that mean HbA1C was remarkably higher in cases than controls and found to be of statistical significance (p<0.001). In both male and female participants mean HbA1C levels are higher in IDA patients than in non–IDA. Here, we significantly demonstrated that iron deficiency anemia not only increases A1C levels in controlled diabetic individuals but also it can interfere with its ability to determine glycemic status of diabetic individuals.In patients with iron deficiency anaemia, negative correlation was found between haemoglobin and HbA1C but of no statistical significance (r=–0.243,p=0.089). This finding shows no significant linear association between haemoglobin & HbA1C. Though IDA had significant linkage with elevation of HbA1C. However, Hb played no predominant role in elevating A1C. These two findings are paradoxical