Volume : V, Issue : I, January - 2015

INHIBITORY EFFECT OF 17–BETA ESTRADIOL ON HEPATOCELLULAR CARCINOMA CELL LINE

F. Kavoosi, M. Nikbakht Dastjerdi

Abstract :

Hepatocellular carcinoma is one of the major malignant diseases in the world today. Phytoestrogens are a group of natural compound with estrogen–like activity.The aim of the present study was to analyse the apoptotic and antiprolifrative effect of 17–beta estradiol in the hepatocellular carcinoma PLC/PRF5 cell line. Materials and Methods: Cells were treated with various concentration of E2 and the MTT assay was used. Furthermore, Cells were treated with single dose of E2 (25µM) and flow cytometry assay was performed.Results: E2 inhibited the growth of liver cancer cells and induced apoptosis significantly with a time– and dose–dependent manner.Discussion: Our finding clearly indicated that E2 has a significant inhibitory effect and induces apoptosis with a dose– and time–dependent manner.Conclusion : E2 can significantly inhibit the growth of HCC cells and plays a significant role inapoptosis of this cell line .

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

F. kavoosi, M. Nikbakht Dastjerdi INHIBITORY EFFECT OF 17-BETA ESTRADIOL ON HEPATOCELLULAR CARCINOMA CELL LINE Indian Journal of Applied Research, Vol.5, Issue : 1 January 2015

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