Volume : VI, Issue : XII, December - 2016
INTERPLAY OF CYP1B1 POLYMORPHISMS IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION
K. L. Chaitra, Shivani Vadapalli, Bks Sastry, Pratibha Nallari
Abstract :
Idiopathic Pulmonary Arterial Hypertension (IPAH) is a disorder of the pulmonary arteries, wherein, due to thickening of the pulmonary arteries, a resistance in the flow of blood is seen, resulting in increased pulmonary arterial pressure. Though the primary cause of the disease is unknown, with the advancement of science, the same may be delineated. A discordance is seen in the genders affected by the disorder. To examine whether CYP1B1, an estrogen metabolizing enzyme is involved in the pathogenesis of IPAH, this study was carried out. Two polymorphisms in CYP1B1, viz., L432V (rs1056836) and A119S (rs1056827) are considered here. Both protective and risk–conferring roles of the alleles have been established by the study, which are in accordance and substantiated by statistical analyses
Keywords :
Idiopathic Pulmonary Arterial Hypertension Xenobiotic Estrogen metabolizing enzymes single nucleotide polymorphisms
Article:
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DOI : 10.36106/ijar
Cite This Article:
K.L. Chaitra, Shivani Vadapalli, BKS Sastry, Pratibha Nallari, INTERPLAY OF CYP1B1 POLYMORPHISMS IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION, Indian Journal of Applied Research,Volume : 6 | Issue : 12 | December 2016
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K.L. Chaitra, Shivani Vadapalli, BKS Sastry, Pratibha Nallari, INTERPLAY OF CYP1B1 POLYMORPHISMS IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION, Indian Journal of Applied Research,Volume : 6 | Issue : 12 | December 2016
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