Volume : IV, Issue : X, October - 2014

Intramuscular Single Dose one Compartmental Toxicokinetics of Lead in Duttaphrynus Melanostictus

Malaya R. Mahananda

Abstract :

Lead continues to receive as much attention as any modern environmental health risk, despite years of intensive research, educational efforts, and remedial measures. The present study examines toxicokinetics of Pb in Indian Common Toad after an intramuscular injection at 15 mg/kg.Samples of the blood, were obtained from Indian Common Toad at times between 2 to 16 h at even hour. The concentrations of Pb in the blood and tissues were determined by atomic absorption spectrometry. Toxicokinetic parameters such as MRT, Vd , Vss, kel, t1/2ß, Tmax, Cmax, CL, AUC0–∞ , AUMC0–∞ of Pb were calculated from the mean metal concentrations in the blood.The highest concentration of Pb in the blood, appeared 2 h after the injection.The concentration of lead in blood ranged from 0.90–3.48 μg/ml. The Vss of 12.40 L/kg in blood, CL of 0.73 L/h/kg in Blood and t1/2ß of 10.43 h in Blood, The Appar

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Malaya R. Mahananda Intramuscular Single Dose one Compartmental Toxicokinetics of Lead in Duttaphrynus Melanostictus. Indian Journal of Applied Research, Vol.4, Issue : 10 October 2014

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