INTRAVENOUS GRANISETRON ATTENUATES HYPOTENSION DURING SPINAL ANAESTHESIA IN CESAREAN DELIVERY: A DOUBLE-BLIND, PROSPECTIVE RANDOMIZED CONTROLLED STUDY

Dr. Shanthi Paulraj; Dr. Leo Sundararajan; Dr. Ahamed Ashar Ali

Volume : VIII, Issue : III, March - 2018

INTRAVENOUS GRANISETRON ATTENUATES HYPOTENSION DURING SPINAL ANAESTHESIA IN CESAREAN DELIVERY: A DOUBLE-BLIND, PROSPECTIVE RANDOMIZED CONTROLLED STUDY

Dr. Shanthi Paulraj, Dr. Leo Sundararajan, Dr. Ahamed Ashar Ali

Abstract :

AIM : To determine the effectiveness of intravenous (IV) granisetron in the prevention of incidence of hypotension and adycardia during spinal anaesthesia in elective caesarean section.

MATERIALS AND METHODS : 80 ASA grade 1 or 2 patients undergoing elective cesarean section under spinal anaesthesia. Before GROUP I Patients received 1 mg Granisetron diluted in 10 ml of normal saline slowly IV (over 1 minute) 5 minute before spinal anaesthesia. GROUP II Patients received 10 ml of normal saline (placebo) slowly IV (within 1 minute) 5 minute before spinal anaesthesia. The following parameters were noted. (1) Time of injection of subarachnoid block. (2) Time of onset of sensory block at T10 level. (3) Time of onset of motor block. (4) Time for sensory regression to T 12 dermatome. 5) Duration of surgical procedure. OBSERVATION AND RESULTS :

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The average time taken for the onset of motor block (Modified omage score 3) was 2.20 minutes in Group I and 2.33 minutes in Group II. It was statistically not significant (p value 0.543 > 0.05).The time of sensory regression to T12 was shorter in Group I (102.30 ± 7.753) when compared with Group II (128.13 ± 8.401) & it was statistically significant (p value = 0.000 < 0.05) . CONCLUSION : Granisetron given as a dose of 1 mg intravenously before spinal anaesthesia in parturients who undergoing cesarean sections has the faster onset of sensory regression to T12 and reduced incidence of hypotension. .