Volume : VII, Issue : XII, December - 2017

LABETALOL Vs METHYLDOPA IN THE TREATMENT OF MILD TO MODERATE PREGNANCY INDUCED HYPERTENSION

Dr. D. Padmaja, Dr. B. Varalakshmi

Abstract :

 Pregnancy induced hypertension (PIH) is one of the major causes of maternal mortality and morbidity. MATERIALS AND METHODS: A prospective study aimed to compare the antihypertensive efficacy of alpha methyldopa and labetalol in treatment of mild to moderate PIH patients between 20 wks and 36 wks of gestation who are randomly selected to labetalol (group I) or alpha methyldopa (group II). Duration of antihypertensive treatment required and pregnancy outcome were noted and analysed statistically. RESULTS: Majority of the patients (91%) recruited for drug therapy belonged to 15 – 25 years. Primigravidae were 69% and multiparae 31%. Both the groups showed significantly lower MAP than pre treatment level (Labetalol group p <0.001 vs Methyldopa group p < 0.01) after three days of treatment.  Labetalol group showed significant improvement of proteinuria when compared with Methyldopa group (p < 0.001), there was no deterioration in this group. In Methyldopa group 8% of patients showed deterioration of proteinuria and only 4% of patients showed improvement of proteinuria. No significant difference in 1 minute Apgar score and mean birth weights in both groups. CONCLUSIONS: Labetalol has better effect on controlling hypertension than Methyldopa with minimum dosage with decreased  proteinuria.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr.D.PADMAJA, Dr.B.VARALAKSHMI, LABETALOL Vs METHYLDOPA IN THE TREATMENT OF MILD TO MODERATE PREGNANCY INDUCED HYPERTENSION, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-12 | December-2017

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