Langerhans Cell Histiocytosis: Morphology and Immunohistochemistry still remain the important keys for diagnosis

Dr. Mona Bargotya; Dr. Ankita Mehta; Dr. Rajni Parmar; Dr. Tejinder Singh

Volume : VIII, Issue : V, May - 2018

Langerhans Cell Histiocytosis: Morphology and Immunohistochemistry still remain the important keys for diagnosis

Dr. Mona Bargotya, Dr. Ankita Mehta, Dr. Rajni Parmar, Dr. Tejinder Singh

Abstract :

Langerhans cell histiocytosis (LCH) is a rare clonal proliferation disorder of cells with phenotype of activated Langerhans cells. It encompasses a spectrum of diseases characterized by the proliferation and infiltration of organs by pathological Langerhans cells. It occurs mostly in children and young adults and involves one or more body systems. It may have a variable clinical course with remissions and relapses. It occurs mostly in children and young adults and involves one or more body systems such as bone, hypothalmus, posterior pitutary gland, lymph nodes, liver or various soft tissues. It is twice as frequent in males as compared to females, and can occur in all the ages. We conducted a retrospective study, in which all the diagnosed cases of LCH, from November 2016 to October 2017were selected. Clinical details, Hematoxylin and eosin (H & E)stained and immunohistochemistry (IHC) slides were retrieved from the records.