LIPID PROFILE AND OXIDATIVE STRESS MARKER IN PRE –& POST– HEMODIALYSIS.

Dr. Shilpa Kasat; Dr. C. R. Mallikarjun; Dr. K.S. Ghorpade; Dr Kumud N Harley; Dr. Narendra Dange; Dr. prerna Nandedkar

Volume : IX, Issue : VI, June - 2019

LIPID PROFILE AND OXIDATIVE STRESS MARKER IN PRE –& POST– HEMODIALYSIS.

Dr. Shilpa Kasat, Dr. C. R. Mallikarjun, Dr. K. S. Ghorpade, Dr Kumud N Harley, Dr. Narendra Dange, Dr. Prerna Nandedkar

Abstract :

Introduction: Dyslipidemia and increased oxidative stress are the causes for accelerated atherosclerosis with high cardiovascular morbidity and mortality in Chronic renal failure (CRF) patients. Objectives: 1) To evaluate oxidative stress and lipid profile in pre– and post hemodialysis CRF patients. Methodology : 40 CRF cases undergoing hemodialysis were selected . Serum lipid parameters like Triglycerides, Total cholesterol , HDL –Cholesterol were estimated by commercially available kits & Serum Malondialdehyde (MDA) was estimated by Thiobarbituric acid method. Result: Significantly reduced HDL–C (P>0.001) & increased blood urea, serum creatinine, Total cholesterol, LDL –cholesterol, Triglycerides (P>0.001) in pre as compared to post dialysis CRF patients were observed. As Compared to pre serum MDA significantly increased in post–hemodialysis. Conclusion: Hemodialysis leads to oxidative stress with increased generation of oxidized low density lipoproteins and chronic deficiency of antioxidants which in turn accelerate the process of atherosclerosis resulting in cardiovascular complication.