Local application of Cisplatin soaked gauge in neck intraoperatively in head and neck cancers short term outcome.

DR. SANJAY M. DESAI; DR.SANJAY SHARMA S.R.; DR. D. AGRAWAL; DR D.Y. MEHTA; DR. M. PANCHOLI

Volume : V, Issue : XII, December - 2015

Local application of Cisplatin soaked gauge in neck intraoperatively in head and neck cancers short term outcome.

Dr. Sanjay M. Desai, Dr. Sanjay Sharma S. R. , Dr. D. Agrawal, Dr D. Y. Mehta, Dr. M. Pancholi

Abstract :

Local delivery of chemotherapeutic drugs has long been recognized as a potential method for reaching high drug doses at the target site while minimizing systemic exposure. Cisplatin is one of the most effective chemotherapeutic agents for the treatment of various tumors; however, its systemic toxicity remains the primary dose–limiting factor Based on the randomized double–blinded phase III trial to determine the effectiveness of cisplatin plus epinephrine in injectable gel form in treating patients who have recurrent or refractory head and neck cancer at U.S. National Institutes of Health we performed a study of local application of cisplatin intraoperatively in the neck& the margins of excised head and neck malignancy and to evaluate its effect.