Volume : V, Issue : V, May - 2015

Long–term outcome of kidney transplantation from deceased donors with early graft dysfunction: a single–center analysis

Ji Shu Ming, Xie Ke Nan, Cheng Dong Rui, Wen Ji Qiu, Chen Jin Song

Abstract :

 Objective The purpose of this stusy was to investigate the correlation factors for early graft dysfunction  after kidney transplantation, and the effects on long–term graft survival. Methods Two hundred and fifty–one recipients of first cadaveric renal graft were divided into four groups according to  the history of acute rejectin(AR) and the concentration of serum creatinine in 6 months(SCr 6mo) after transplantation:  Group A and B,having no history of AR with SCr 6mo <130.0umol/L in the formerand ≥130.0 umol/L in the latter,and  groups C and D having the history of AR with SCr 6mo <130.0umol/L in the formerand ≥130.0 umol/L in the latter. All  groups had the same immunosuppressive protocol. Results 10th day after operation in groups A and C maintained,while the serum creatinine level in group B and D  were obviosly elevated,which was correlated with acute tubular necrosis(ATN), IgA nephritis,donor’s age,postoperative  hypotention,AR times and the dosage of cyclosporine A.The one– and three–year survival rate of renal graft in group D  was significantly lower than groups A,B and C. Conclusion Acute tubular necrosis was the commonest cause for renal graft dysfunction after renal transplanation.The  damage to the kidney in the process of renal removal, ischemia–reperfusion and high dose of cyclosporine A at early  stage might affect the recovery of the early renal function.The dysfunction of early renal dysfunction after operation  would affect the renal graft long–term survival in patients having AR in 6 months after operation.

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Article: Download PDF   DOI : 10.36106/ijar  

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Ji Shu-Ming, Xie Ke-Nan, Cheng Dong-Rui, Wen Ji-Qiu, Chen Jin-Song

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