Volume : IX, Issue : IX, September - 2019

Loss of hetrozygosity as a marker of tumor progression in oral squamous cell cancer

Dr Nitu Sharma, Dr Rajat K Sharma

Abstract :

Cancer is the second leading cause of death globally. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy. The survival rate is directly proportional to the stage of the disease. Genetic alterations are known to occur during carcinogenesis. Concept of LOH (Loss of heterozygosity) developed with the discovery of tumor suppressor gene. Methods: An observational study aimed at studying the LOH at 3p &9p by PCR in HNSCC Results: 30 cases were studied and LOH either at 3p or 9p was seen in all cases, but in varying stages. Interpretation: LOH can be used as a biomarker for studying disease progression in HNSCC

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

LOSS OF HETROZYGOSITY AS A MARKER OF TUMOR PROGRESSION IN ORAL SQUAMOUS CELL CANCER, Dr Nitu Sharma, Dr Rajat K Sharma INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-9 | September-2019

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