Lympho-epithelial ratio in Hashimoto's Thyroiditis; correlation with Thyroid Antibody and Thyroid Hormone Profile - A Prospective study

Dr Deepika; Dr Gopinath Rajesh; Dr Sathyavathi R Alva

Volume : VIII, Issue : IV, April - 2018

Lympho-epithelial ratio in Hashimoto's Thyroiditis; correlation with Thyroid Antibody and Thyroid Hormone Profile - A Prospective study

Dr Deepika, Dr Gopinath Rajesh, Dr Sathyavathi R Alva

Abstract :

Background and objectives: Hashimoto’s thyroiditis (HT) is a chronic autoimmune thyroid disease in which genetic and environmental factors play a role in the etiology. In addition, it remains the leading cause of hypothyroidism throughout the world. This study records the lympho–epithelial (LER) ratio in Hashimoto’s Thyroiditis and its correlation with the thyroid hormones and antibody.

Materials and methods: 100 patients with cytological diagnosis of Hashimoto’s thyroiditis (HT) in a period of 1year were enrolled in the study. We recorded the results of the free triiodothyronine (T3), free thyroxin (T4), Thyroid stimulating hormone (TSH) and anti –thyroid peroxidase (anti–TPO) and also calculated the lympho–epithelial (LER) ratio of each case.

Results: Lympho–epithelial ratio showed a statistically significant positive correlation with the thyroid antibody. Furthermore, a negative but statistically significant correlation was determined between the lympho–epithelial ratio and thyroid hormones (T3 and T4).

Conclusion: LER can be a valuable and practical parameter for monitoring HT .