Volume : IX, Issue : V, May - 2019

Malignant Epitheloid Gastrointestinal Stromal Tumour:A Case Report

Dr. Muktanjalee Deka, Dr. Shruti Chakravartty

Abstract :

Gastrointestinal Stromal Tumours (GIST) are rare mesenchymal tumours, arising from interstitial cells of Cajal, accounting for approximately 1–3% of all gastrointestinal tumours. Epitheloid GIST previously termed as “Leiomyoblastoma” accounts for only 20% of all GIST. Molecular mechanism reveals a mutation of KIT (80–90%), PDGFRA (5%) and expresses CD–117(80–90%), CD–34(80–85%), SMA (18%), S–100(<1%)[6], Desmin(2%) and Cytokeratin(2%). DOG1 (99%) is sensitive and specific for GIST. We present a case of 55 years old female with history of melaena and pain abdomen for 1 year. MDCT reveals a mass of size 7.2x6.2 cm2 in jejunal mesentery adherent with a segment of small bowel loop. Resection of the tumour was done along with adjacent small intestine and specimen was sent for histopathological examination. Size of the tumour was 8x8x6 cm3 and on microscopy, it showed fascicular arrangement of epitheloid cells with hyperchromatic and pleomorphic nuclei with prominent nucleoli and eosinophilic cytoplasm. Mitotic rate was 2/50 hpf, hence diagnosed as Epitheloid GIST with high malignant potential (Considering location, size and mitotic rate). Diagnosis was confirmed by immunohistochemistry (CD–117+ve). Prognosis of epitheloid GIST depends on size of the tumour and mitotic rate. Targeted therapy has been developed against KIT (CD–117) mutation.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

MALIGNANT EPITHELOID GASTROINTESTINAL STROMAL TUMOUR:A CASE REPORT, Dr. Muktanjalee Deka, Dr. Shruti Chakravartty INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-5 | May-2019

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