Mancozeb fungicide induced toxicity in level of lipid Per oxidation LPO and Hydrogen Peroxide HO in the  crude homogenate, Mitochondrial and Microsomel rich fraction of testes in  Adult albino Rats

Dr.G.Ananthan

Volume : VII, Issue : VII, July - 2017

Mancozeb fungicide induced toxicity in level of lipid Per oxidation LPO and Hydrogen Peroxide HO in the crude homogenate, Mitochondrial and Microsomel rich fraction of testes in Adult albino Rats

Dr. G. Ananthan

Abstract :

Mancozeb, a fungicide of ethylenebisdithiocarbamate (EBDC’s) group is a polymeric complex of 20% manganese with 2–5% zinc salt. It is commonly used for foliar application and seed treatment in agriculture. Low acute toxicity, Mancozeb has been shown to produce adverse effects on reproduction, liver, kidney, central nervous system and chromosomes of bone marrow cells in mice and rats. The present study is undertaken to assess the protective effect of Vitamin C against Mancozeb induced toxicity in the Testis of adult albino rats. 90 days old adult male wistar rats (Rattus norvegicus) were exposed to Mancozeb at the dose of 300mg/kg body weight, orally for 60 days. The Control group received the Olive oil alone as vehicle. Administration of Mancozeb the levels of lipid peroxidation and hydrogen peroxide were significantly elevated in crude homogenate, Mitochondrial and Microsomal of testis in Mancozeb treated rats, when compared to control. The lipid peroxidation level and hydrogen peroxide remained normal in animals treated with vitamin C and Mancozeb. However, vitamin C treated rats did not show any significant alteration in the levels of lipid peroxidation and hydrogen peroxide. Further, withdrawal of Mancozeb restored the levels of H₂O₂ and LPO to normalcy, compared to control rats. The present study reveals the protective effect of vitamin C on the Mancozeb induced Testicular toxicity in the adult rats.