Matrix Metalloproteinase�1 gene polymorphism is associated with the prognosis of Hepatocellular Carcinoma in Egyptian population

Faten Zahran; Abrahim Mohey; Islam Hamdy

Volume : III, Issue : XII, December - 2013

Matrix Metalloproteinase�1 gene polymorphism is associated with the prognosis of Hepatocellular Carcinoma in Egyptian population

Faten Zahran, Abrahim Mohey, Islam Hamdy

Abstract :

Normal 0 false false false EN–US X–NONE X–NONE /* Style Definitions */ table.MsoNormalTable {mso–style–name:"Table Normal"; mso–tstyle–rowband–size:0; mso–tstyle–colband–size:0; mso–style–noshow:yes; mso–style–priority:99; mso–style–qformat:yes; mso–style–parent:""; mso–padding–alt:0in 5.4pt 0in 5.4pt; mso–para–margin:0in; mso–para–margin–bottom:.0001pt; mso–pagination:none; font–size:11.0pt; font–family:"Calii","sans–serif"; mso–ascii–font–family:Calii; mso–ascii–theme–font:minor–latin; mso–hansi–font–family:Calii; mso–hansi–theme–font:minor–latin;} This study aimed to examine the relationship between the gene polymorphism of MMP–1 and the prognosis of hepatitis C virus (HCV)–related hepatocellular carcinoma (HCC) in Egyptian population. Methods: The study enrolled 180 Egyptian individuals classified into 3 groups Group I: consists of 60 apparently healthy individuals served as control Group II: consists of 60 individuals diagnosed with HCV Group III: consists of 60 individuals diagnosed with HCC. Gene polymorphism of MMP–1 –1607 1G/2G using restriction fragment length polymorphism (RFLP) for amplified genomic DNA was analyzed. Results: In HCC prognosis, MMP–1 2G carriers had higher probability of developing HCC when compared to healthy individuals. Conclusion: MMP–1 2G allele may be a cooperative risk factor for poor prognosis in HCC patients, suggesting that further studies with larger sample size should be investigated to ensure that this gene polymorphism might be a potential marker for predicting the prognosis of HCC patients in Egyptian patients.