MDA, OXIDATIVE STRESS MARKER–ROLE IN DIABETIC NEPHROPATHY WITH SPECIAL REFERENCE TO TYPE II DIABETES MELLITUS

KHUSHBU RANI; PRATIBHA GAVEL; SUJIT BHARTI

Volume : VI, Issue : V, May - 2016

MDA, OXIDATIVE STRESS MARKER–ROLE IN DIABETIC NEPHROPATHY WITH SPECIAL REFERENCE TO TYPE II DIABETES MELLITUS

Khushbu Rani, Pratibha Gavel, Sujit Bharti

Abstract :

 OBJECTIVE: To investigate the role of oxidative stress marker, MDA levels among type II diabetic patients with and without nephropathy, and to determine its correlation with duration and other biochemical parameters (FBG, HbA1C, MDA, Micro– Albuminuria ). METHOD: Blood Glucose level was estimated by GOD– POD method, Glycosylated haemoglobin by Ion exchange resin method, Microalbuminuria by Pyrogallol red method (end point1 ) and MDA by colorimetric method as described by Ohkawa et al . RESULTS: The present study showed the significant increase in the fasting blood glucose (FBG) and glycated haemoglobin (HbA1C) levels in complicated and non–complicated diabetic patients with nephropathy as compared to healthy controls. The MDA levels were significantly correlated with duration of diabetes in complicated cases which was also highly significant. CONCLUSION: The study concludes that diabetic patients suffer more from oxidative stress compared to healthy control. Oxidative stress is still higher in diabetic patients with nephropathy than diabetics without nephropathy