MEDICINAL APPLICATION OF NAPHTHYL–ISO–QUINOLINE ALKALOID FROM ANCISTROCLADUS  A Review

Anil Karn; Maheshwar Sharon; Madhuri Sharon

Volume : VI, Issue : II, February - 2016

MEDICINAL APPLICATION OF NAPHTHYL–ISO–QUINOLINE ALKALOID FROM ANCISTROCLADUS A Review

Anil Karn, Maheshwar Sharon, Madhuri Sharon

Abstract :

Ancistrocladus is a tropical liana plant. All species of Ancistrocladus are known to have different types of Naphthyl iso–quinoline (NIQ) alkaloids. NIQ alkaloids are unique because their basic structure comprises of a biaryl system consisting of naphthalene and a tetra hydro quinoline moiety and these alkaloids display atropisomerism due to the bulky ortho–substutients adjacent to the biaryl axis. NIQs highly unusual structure is due to an unprecedented biogenetic origin, for which a polyketide pathway has been assumed. Researchers have shown that these alkaloids exhibit interesting biological activities, such as Anti–HIV, Anti–malarial, Anti–tumor, Anti–microbial and spasmolytic activity. This review reports various initial attempts to study the medicinal property of NIQ alkaloids found in genus Ancistrocladus.