Volume : IV, Issue : I, January - 2014

Melatonin Protection on Fluoride Induced Neurotoxicity in the Male Rat

Raveendrababu Meda, Rajendra N. Bhatt, Dhara D. Vyas, Mandava V. Rao

Abstract :

This study was conducted to investigate effects of sodium fluoride (NaF) on ain (cereal hemisphere) of rat and its possible amelioration by melatonin. Adult male Wistar rats (Rattus novergicus) were administered sodium fluoride (NaF) at the doses of 5 and 10 mg/kg body weight and melatonin 10 mg/kg body weight for 60 days. Gravimetric and biochemical indices were done of ain an also studied. The increased lipid peroxidation (LPO) indicated an oxidative stress and the elevated fluoride levels in ain tissue could be the result of the inhibition of antioxidant enzymes (SOD, CAT) in the ain region of rats fed with fluoride. These changes were correlated with accumulation of fluoride in the region. However, these effects were ameliorated by co-supplementation of melatonin along with NaF in rats, because of its antioxidant cascade phenomenon.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Raveendrababu Meda, Rajendra N. Bhatt, Dhara D. Vyas, Mandava V. Rao Melatonin Protection on Fluoride Induced Neurotoxicity in the Male Rat Indian Journal of Applied Research, Vol.IV, Issue. I

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