Melorheostosis With Unusual Paraarticular Ossification and Long–Term Follow Up–A Case Report

Anastasika Poposka; Milan Samardziski; Roza Dzoleva–Tolevska; Nenad Atanasov

Volume : V, Issue : III, March - 2015

Melorheostosis With Unusual Paraarticular Ossification and Long–Term Follow Up–A Case Report

Anastasika Poposka, Milan Samardziski, Roza Dzoleva Tolevska, Nenad Atanasov

Abstract :

Melorheostosis is a rare bone disease characterized by a “flowing” hyperostosis of the cortex, first described in 1922 by Léri and Joanny. It frequently involves a single limb characterized by hyperostotic linear bone densities. The radiographic appearance has been linked to “dripping wax down one side of a candle”. It has been suspected that melorheostosis is due to a loss–of–function mutation in LEMD3 gene (also called MAN1), which encodes an inner nuclear memane protein. However, the etiology of melorheostosis remains unknown. We report a case of a 72–year–old male patient, with unusual for the desease paraarticular ossification, whose left leg was affected by melorheostosis more than 37 years ago.