Metalloproteinase (MMPs) As Prognostic and Diagnostic Tool in Periodontics–A Review

Dr. Bhoomika Khosya; Dr. Devaraj C.G.; Dr.Spiti Datta

Volume : IV, Issue : X, October - 2014

Metalloproteinase (MMPs) As Prognostic and Diagnostic Tool in Periodontics–A Review

Dr. Bhoomika Khosya, Dr. Devaraj C. G. , Dr. Spiti Datta

Abstract :

Matrix Metalloproteinase (MMPs)are group of enzyme that in concert are responsible for the degradation of most extracellular matrix proteins during organogenesis,growth and normal tissue turnover. The expression and activity of MMPs in adult tissue is normally quite low, but increases significantly in various pathological condition that may lead into unwanted tissue destruction,such as in inflammatory disease,tumor growth and metastasis. MMPs have a marked role in tissue destructive oral disease.the role of collagenase,especially MMP–8 in periodontitis and peri–implantitis is the best known example of unwanted tissue destruction related to increased presence and activity of MMPs at site of disease.