Volume : IX, Issue : I, January - 2019

MIFEPRISTONE IN THE MEDICAL MANAGEMENT OF UTERINE FIBROIDS

Dr. Alakananda, Dr. B. Basumatary, Dr. B. Sreeja Reddy

Abstract :

Leiomyoma is the common benign tumor of uterus with maximum incidence between 35–45 years of age.It is a common indication for hysterectomy in India. An effective medical treatment option may reduce hysterectomy and associated morbidity. So this study was conducted to evaluate the effect of low dose mifepristone on uterine fioids. Methodology : A total of 50 patients with symptomatic fioids were enrolled in this hospital based prospective study. Hemogram, liver function tests, ultrasound and endometrial histology was performed. Patients were given oral Mifepristone 25mg/day for 3 months and followed at 3 and 6 months. Results and Observations: Mean myoma volume decreased by 30.69% at 3 monthsand 42.49% at 6 months. Mean uterine volume decreased by 17.39% at 3 months and 16.54% at 6 months. 34% patients showed endometrial thickness≥10mm after the treatment. Mean PBAC score reduced by 96.53% at 3 months and 65.83% at 6 months. Mean VAS for dysmenorrhea reduced by 81.18% at 3 months and 29.7% at 6 months. 84.61% developed amenorrhoea at the end of 3 months. No major side effects were noted during the course of the study. Conclusions: Our study concluded that low–dose mifepristone is useful in case of symptomatic moderate sized leiomyoma.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

MIFEPRISTONE IN THE MEDICAL MANAGEMENT OF UTERINE FIBROIDS, Dr. Alakananda, Dr.B.Basumatary, Dr.B.Sreeja Reddy INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-1 | January-2019

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