Volume : IX, Issue : II, February - 2019

Misfolded Tau in the Retina

Umur A. Kayabasi

Abstract :

Introduction: Tau protein plays a crucial role in many neurodegenerative diseases including Alzheimer‘s disease (AD). Tau inclusions and amyloid beta (AB) depositions have been described in the post–mortem retina exams of AD patients. Cryo–electron microscopy (Cryo EM) was recently used to detect the detailed structure of Tau filaments. Methods and Result: We examined the retinas of PET–proven live AD patients by spectral domain optical scanning tomography (SD– OCT) and fundus autofluorescein (FAF). The hyper or hypofluorescent lesions in the retina were scanned by OCT and images that completely corresponded with the histopathological and Cryo– EM shapes of Tau filaments were observed. Conclusion: Retinal Tau is a very promising target to detect early changes in AD and retinal imaging may be an exciting and trustable technique to predict and monitor the disease

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

MISFOLDED TAU IN THE RETINA, Umur A. Kayabasi INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-2 | February-2019

Number of Downloads : 180

References :