Misoprostol versus 15 Methyl PGF2 Alpha for Mid–trimester Medical Abortion of pregnancy

Dr. Sangita Nangia Ajmani; Dr. Vinita Sarbhai

Volume : VI, Issue : IV, April - 2016

Misoprostol versus 15 Methyl PGF2 Alpha for Mid–trimester Medical Abortion of pregnancy

Dr. Sangita Nangia Ajmani, Dr. Vinita Sarbhai

Abstract :

OBJECTIVE : Progesterone derivatives in various forms and dosages have been used for early second trimester abortions. But still a standard protocol has not been devised. Keeping this in mind this study was carried out in Kasturba Hospital on patients coming for mid–trimester termination of pregnancy between 13 to 20 weeks of gestation. METHODOLOGY : Group I included 20 patients who received vaginal misoprostol 400 microgram every 3 hours to a maximum of 5 doses. Group II included 20 patients who received 15 methyl PGF2 alpha 250 micrograms every 3 hours. Parameters observed were– induction abortion interval, incidence of incomplete abortion, adverse effects of drugs and success rate. RESULTS : In–group I, 18 out of 20 patients, aborted within 48 hours, with a mean induction abortion interval of approximately 13 hours as compared to Group II in which 16 aborted within 48 hours with mean induction abortion of approximately 17 hours. 17 out 18 successful cases had complete abortion in group I as compared to 13 out of 16 in group II. CONCLUSION : The study showed that the use of vaginal Misoprostol for early second trimester abortion resulted in a higher success rate than intramuscular 15 methyl PGF2 alpha and is associated with shorter induction abortion interval. Incidence of incomplete abortion and other side effects reported with misoprostol are also less. Considering good shelf life of vaginal misoprostol, high efficacy, convenience in application, low cost and better patient compliance, it becomes the most suitable drug for mid trimester MTP in our study.