MITOMYCIN–C USE IN TREATMENT OF EPITHELIAL AND FIBROUS DOWNGROWTH– A RARE COMPLICATION OF ANTERIOR SEGMENT SURGERY

Dr. Kokila G. Kamath; Dr. Bhushan V. Chaudhari; Dr. Ridhima Sakhuja

Volume : IX, Issue : VIII, August - 2019

MITOMYCIN–C USE IN TREATMENT OF EPITHELIAL AND FIBROUS DOWNGROWTH– A RARE COMPLICATION OF ANTERIOR SEGMENT SURGERY

Dr. Kokila G. Kamath, Dr. Bhushan V. Chaudhari, Dr. Ridhima Sakhuja

Abstract :

Mitomycin–C is an alkylating, anti tumour antibiotic, generally used in surgery because of its ability to inhibit fioblast proliferation and to suppress vascular downgrowth. One of Mitomycin’s active metabolites cross links with DNA, causing selective interruption of DNA replication, thus inhibiting mitosis of protein synthesis. Epithelial and fious downgrowth after anterior segment surgery are rare surgical complications that can cause devastating secondary glaucoma. It occurs when epithelium or connective tissue invades the anterior chamber through a defect in a wound site. Risk factors for the development of these entities include prolonged inflammation, wound dehiscence, delayed wound closure or descemet’s memane tear. It is an aggressive, vision threatening complication of anterior segment surgery. It is difficult to manage resulting in poor prognosis. In our study, Mitomycin C in the concentration of 0.05 to 0.1mg/ml was given subconjunctivally to treat patients with epithelial and fious downgrowth with good clinical outcome.