Molecular and Biochemical Studies on Subjects with Increased Waist Circumference

Sumina Cherian; Sharmila K; Jiju JS; Aswathy Sundaresh; Sreesha SR; Sreekutty G; Dinesh Roy D

Volume : VI, Issue : V, May - 2016

Molecular and Biochemical Studies on Subjects with Increased Waist Circumference

Sumina Cherian, Sharmila K, Jiju Js, Aswathy Sundaresh, Sreesha Sr, Sreekutty G, Dinesh Roy D

Abstract :

<p>&nbsp;Waist circumference (WC) is a simple measurement to indicate the need for weight management and is a convenient way of measuring abdominal or central obesity. WC appears to increase the risk of obesity related complications and several chronic illnesses including cardiovascular disease (CVD) and excess mortality. Overweight and obesity have been increasing within the UK population over the past 15 years among both adults and children. This trend is also being observed in other countries. Goal of the present study was to find out the effect of molecular and biochemical studies on subjects with increased waist circumference. The present study consists of 45 study subjects and 25 healthy subjects without any chronic illness were selected as control for this study. Detailed demographic, clinical and lifestyle characteristics were compared with subjects. The role of oxidative stress was measured by Malondialdehyde (MDA) and the DNA damages were quantified by Cytokinesis&ndash;Block Micronuclei (CBMN) assay. The mean MDA value and the micronuclei frequency was significantly elevated in study subjects as compared with that of control subjects. Abdominal fat is closely involved in the production of oxidative stress. This suggests that molecular and biochemical effects may be one of the important causes for abnormal abdominal fat with increased waist circumference.</p>