MONITORING OF CD4 RESPONSE OVER A PERIOD OF THIRTY SIX MONTHS IN PATIENTS OF HIV/AIDS ON ART:A STUDY IN OSMANIA GENERAL HOSPITAL

Dr.R. Siddeswari; Dr. B. Sudarsi; Dr.N. Srinivasa rao; Dr.Abhilash.T

Volume : VI, Issue : III, March - 2016

MONITORING OF CD4 RESPONSE OVER A PERIOD OF THIRTY SIX MONTHS IN PATIENTS OF HIV/AIDS ON ART:A STUDY IN OSMANIA GENERAL HOSPITAL

Dr. R. Siddeswari, Dr. B. Sudarsi, Dr. N. Srinivasa Rao, Dr. Abhilash. T

Abstract :

<p>&lt;p&gt;&amp;nbsp;Aim:The present study aims to assess the progression of CD4 cell count after initiation of ART in patients with HIV/AIDS with different mean CD4 cell counts at the time of presentation. MATERIAL AND METHODS:It was a retrospective hospital based observational study. Data was collected over a period of 4 years from 2005 to 2009 in the ART CENTRE, Department of Medicine, Osmania General Hospital. We included 182 HIV/AIDS who were on ART. CD4 cell count data was collected and assessed for changes in mean CD4 cell count after ART initiation. Investigations:Complete blood picture, serum creatinine, Blood urea, serum electrolytes, Liver function tests, Sputum for Acid fast bacilli, Chest radiography, CD4 cell Count were done to all patients , Fine needle aspiration and biopsy(if necessary), Magnetic Resonance imaging (if necessary), Computerized Tomography(if necessary), Colonoscopy(if necessary). RESULTS:Out of 182 patients, 100 were male and 82 were female which were categorised into 4 groups as per base line mean CD4 cell count . Group 1 includes CD4 cell count &amp;lt; 50 n= 10; group 2 with CD4 cell count between 51 to &amp;lt; 100 n= 30; group 3 with CD4 cell count between 101 to 200 n= 83 and group 4 with CD4 cell count &amp;lt; 250 n= 59. In group 1, base line mean CD4 cell count of 31.08 cells/mm3 improved to 307.90 cells/mm3 ,in group 2 CD4 cell count improved from baseline of 80.30 cells/mm3 to 337.27 cells/mm3 , in group 3 with baseline CD4 cell count of 160.08 cells/mm3 improved to 422.99 cells/mm3 and in group 4 CD4 cell count baseline of 222.95 increased to 423.44 cells/mm3 after 36 months of ART. CD4 cell counts improvement is more in younger patients (age &amp;lt; 20 years[n = 4]) with baseline count of 142.52 to 639.50 cells/mm3(468.98) compared to patients with age &amp;gt; 40 years age (n= 39) with baseline mean CD4 cell count 153.31 to 419.19 cells/mm3(265.88) . Conclusion:This study shows definite improvement in the CD4 cell count after initiation of ART. Regular intake of ART will improve immunologic response and improve CD4 cell counts irrespective of base line CD4 cell count. Most of the patients are falling in age group between 21&amp;ndash;40 years n=139. CD4 cell counts improvement is maximum in first six months post ART initiation and more in younger age groups.&lt;/p&gt;</p>